Chemical Reaction and Harm of Thioacetic Acid
Release time：2024-05-31
Thioacetic acid is an organic compound, colorless to pale yellow transparent liquid, with a strong thiol odor. It is used for the introduction of thiol groups in organic synthesis.
Nature
Thioacetic acid is a yellow fuming liquid with a pungent odor. It can be decomposed into acetic acid and hydrogen sulfide, soluble in ethanol, soluble in water and ether, more soluble in hot water. Relative density (d104)1.075. The freezing point is <-17 ℃. Boiling point 93 ℃. Refractive index (n?20D)1.4630. Flash point <1 ℃. Flammable.
chemical reaction
Thioacetate from the dissociation of thioacetic acid can be used to prepare thioacetate esters. Hydrolysis of the thioacetate produces thioacetic acid. From the reaction of sodium thioacetate and a halogenated hydrocarbon, thioacetate can be prepared. Some of the reactions are as follows:
CH3C(O)SH NaOH → CH3C(O)SNa H2O
CH3C(O)SNa RX → CH3C(O)SR NaX(X = Cl, Br, I, etc.)
CH3C(O)SR 2 NaOH → CH3CO2ON
RSNa HCl → RSH NaCl
Preparation
Thioacetic acid can be obtained by the reaction of acetic anhydride and hydrogen sulfide:
(CH3C(O)2O H2S → CH3C(O)SH CH3CO2H
Hazards
Median lethal dose (mouse, intraperitoneal) 75 mg/kg. It is lacrimal and corrosive.
Hazardous characteristics: flammable, in case of open flame, high heat or contact with oxidant, there is a risk of combustion and explosion. It is decomposed by high heat to produce toxic sulfide flue gas.
Combustion (decomposition) products: carbon monoxide, carbon dioxide, sulfur oxide, hydrogen sulfide.
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